Anti-Influenza Virus M2e Recombinant Antibody (TCN-032)
CAT#: TAB-508CL
Recombinant Human monoclonal antibody expressed in CHO binding to Influenza Virus M2e. TCN-032 is a human monoclonal antibody targeting a conserved epitope on M2e, was explored in experimental human influenza. TCN-032 may provide immediate immunity and therapeutic benefit in influenza A infection, with no apparent emergence of resistant virus. TCN-032 was safe with no evidence of immune exacerbation based on serum cytokine expression.
Published Data
Tested Data
FuncS
Figure 1 Therapeutic efficacy of anti-M2 mAbs TCN-031 and TCN-032 in mice.
Mice (n = 10) were infected by intranasal inoculation with 5 × LD₅₀ A/Vietnam/1203/04 (H5N1), followed by 3 i.p. injections with mAbs at 24, 72, and 120 h postinfection (a total of three mAb injections per mouse) and weighed daily for 14 d. Percentage-survival is shown.
Grandea, A. G., Olsen, O. A., Cox, T. C., Renshaw, M., Hammond, P. W., Chan-Hui, P. Y., ... & Pekosz, A. (2010). Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses. Proceedings of the National Academy of Sciences, 107(28), 12658-12663.
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SDS-PAGE
Figure 1 Anti-Influenza Virus M2e Antibody (TAB-508CL) in SDS-PAGE
Lane 1: Non-reduced mAb
Lane 2: Reduced mAb
M: SDS-PAGE Marker
SEC-HPLC
Figure 2 Anti-Influenza Virus M2e Antibody (TAB-508CL) in HPLC
The purity of TAB-508CL was greater than 95% as determined by SEC-HPLC.
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Influenza Virus
- Applications
- FuncS
- Related Disease
- Influenza
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Orthomyxoviruses; Influenza Virus
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-508CL, RRID: AB_3111965)
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
| PABX-140 | Recombinant Mouse Anti-M2e Antibody (PABX-140) | WB, ELISA, FuncS | IgG |
| PABX-140-F (E) | Recombinant Mouse Anti-M2e Antibody Fab Fragment (PABX-140-F (E)) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-140-S (P) | Recombinant Mouse Anti-M2e Antibody scFv Fragment (PABX-140-S (P)) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1299-FY | Human Anti-M2E Recombinant Antibody (HPAB-1299-FY) | ELISA | Human IgG |
| HPAB-0980WJ | Recombinant Human Anti-M2e Antibody (8I10) | ELISA, FC | Human IgG |
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| HPAB-0982WJ | Recombinant Human Anti-M2e Antibody (3241_G23) | ELISA, FC | Human IgG |
| HPAB-0983WJ | Recombinant Human Anti-M2e Antibody (3244_I10) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1299-FY-F(E) | Human Anti-M2E Recombinant Antibody; Fab Fragment (HPAB-1299-FY-F(E)) | ELISA | Human Fab |
| HPAB-1300-FY-F(E) | Human Anti-M2E Recombinant Antibody; Fab Fragment (HPAB-1300-FY-F(E)) | ELISA | Human Fab |
| HPAB-0980WJ-S(P) | Recombinant Human Anti-M2e Antibody scFv Fragment (8I10) | ELISA, FC | Human scFv |
| HPAB-0981WJ-S(P) | Recombinant Human Anti-M2e Antibody scFv Fragment (23K12) | ELISA, FC | Human scFv |
| HPAB-0982WJ-S(P) | Recombinant Human Anti-M2e Antibody scFv Fragment (3241_G23) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1299-FY-S(P) | Human Anti-M2E Recombinant Antibody; scFv Fragment (HPAB-1299-FY-S(P)) | ELISA | Human scFv |
| HPAB-0980WJ-F(E) | Recombinant Human Anti-M2e Antibody Fab Fragment (8I10) | ELISA, FC | Human Fab |
| HPAB-0981WJ-F(E) | Recombinant Human Anti-M2e Antibody Fab Fragment (23K12) | ELISA, FC | Human Fab |
| HPAB-0982WJ-F(E) | Recombinant Human Anti-M2e Antibody Fab Fragment (3241_G23) | ELISA, FC | Human Fab |
| HPAB-0983WJ-F(E) | Recombinant Human Anti-M2e Antibody Fab Fragment (3244_I10) | ELISA, FC | Human Fab |
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